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Träfflista för sökning "AMNE:(NATURVETENSKAP Kemi) ;pers:(Antzutkin Oleg);lar1:(slu)"

Search: AMNE:(NATURVETENSKAP Kemi) > Antzutkin Oleg > Swedish University of Agricultural Sciences

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1.
  • Lendel, Christofer, 1976-, et al. (author)
  • A Hexameric Peptide Barrel as Building Block of Amyloid-β Protofibrils
  • 2014
  • In: Angewandte Chemie International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 53:47, s. 12756-12760
  • Journal article (peer-reviewed)abstract
    • Oligomeric and protofibrillar aggregates formed by the amyloid-β peptide (Aβ) are believed to be involved in the pathology of Alzheimer’s disease. Central to Alzheimer pathology is also the fact that the longer Aβ42 peptide is more prone to aggregation than the more prevalent Aβ40. Detailed structural studies of Aβ oligomers and protofibrils have been impeded by aggregate heterogeneity and instability. We previously engineered a variant of Aβ that forms stable protofibrils and here we use solid-state NMR spectroscopy and molecular modeling to derive a structural model of these. NMR data are consistent with packing of residues 16 to 42 of Aβ protomers into hexameric barrel-like oligomers within the protofibril. The core of the oligomers consists of all residues of the central and C-terminal hydrophobic regions of Aβ, and hairpin loops extend from the core. The model accounts for why Aβ42 forms oligomers and protofibrils more easily than Aβ40.
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2.
  • Rusanova-Naydenova, D., et al. (author)
  • Synthesis and structural characterisation of solid titanium(iv) phosphate materials by means of X-ray absorption and NMR spectroscopy
  • 2022
  • In: Dalton Transactions. - : Royal Society of Chemistry. - 1477-9226 .- 1477-9234. ; 51:21, s. 8192-8207
  • Journal article (peer-reviewed)abstract
    • Solid titanium phosphate, TiP, materials hold great promise for wastewater treatment for removal of metal ions and complexes. A series of TiP materials, synthesised at mild conditions and short reaction times, have been structurally characterised using solid-state X-ray absorption spectroscopy, phosphorus and titanium K edge XANES and EXAFS, and 31P and 47/49Ti NMR spectroscopy. The titanium K edge EXAFS data of α-Ti(HPO4)2·H2O (α-TiP) revealed octahedral coordination of oxygens around titanium. Repeated washing of primary β-/γ-TiP with hydrochloric acid results in formation of a weakly ordered solid, TiO(OH)(H2PO4)·H2O, TiP1-H. The structure of TiP1-H is shown by Ti EXAFS to be a titanyl compound, containing a short Ti O bond. The analogous data for linked titanium phosphate compounds (LTP) disclosed that inter-linkage occurs between α-TiP and titanyl phosphate units, supported by 31P-31P NOESY NMR data. 47/49Ti NMR and Ti pre-edge XANES show evidence of two different titanium environments in LTP, one very similar to that observed in TiP1-H and a second more symmetric octahedral environment. Data are discussed in terms of induced acidic hydrolyses of titanium(iv) and phosphate counterpart during washings with hydrochloric acid and water. A straightforward relation between synthesis parameters/post synthetic treatment and structural re-arrangement in the materials is established. 
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